GFUS

Across TCGA pan-cancer cohorts, GFUS mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of GFUS’s most consistent transcriptional readouts.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where GFUS mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types GFUS is over-expressed in tumor, although a few such as HNSC and LSCC show the opposite, repressed pattern.

PDAC, HNSC, and LUAD are the cancer types where GFUS tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GFUS mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
PDAC	Male	III,IV	+0.593	<.001	9	view →
HNSC	Male	All	−0.401	<.001	8	view →
LUAD	All	II,III,IV	+0.284	<.001	7	view →
LSCC	Male	All	−0.199	<.001	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

GFUS–PDAC

Open the PDAC breakdown →