GFRA4

Across TCGA cell cohorts, GFRA4 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GFRA4-associated genes across cancer lineages are CDH20, OR52K1, and ASPN. Each is linked with GFRA4 in more than 1 cancer types. Because this analysis shows association rather than direction, both GFRA4-to-partner and partner-to-GFRA4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CDH20 grouped by GFRA4-low versus GFRA4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GFRA4→partner) and Y-score (partner→GFRA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CDH20 →	+0.081	+4.029	.009	.001	3	1
LARGE_INTESTINE	OR52K1 →	+0.010	+3.217	<.001	.006	3	1
LARGE_INTESTINE	ASPN →	+0.046	+3.426	<.001	.007	1	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

CDH20 by GFRA4 expression — LARGE_INTESTINE

Explore this box plot interactively →