GFRA2

Across TCGA cell cohorts, GFRA2 mutation is significantly associated with the drug of many other genes, with 39 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GFRA2-associated genes across cancer lineages are Eg5_9814, JAK_8517, and 50869. Each is linked with GFRA2 in more than 1 cancer types. Because this analysis shows association rather than direction, both GFRA2-to-partner and partner-to-GFRA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Eg5_9814 grouped by GFRA2-low versus GFRA2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GFRA2→partner) and Y-score (partner→GFRA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Eg5_9814 →	+0.573	+2.807	.039	.045	3	1
LARGE_INTESTINE	JAK_8517 →	+0.653	+2.871	.032	.021	3	1
LARGE_INTESTINE	50869 →	+0.461	+2.871	.020	.021	3	1
LARGE_INTESTINE	GW-2580 →	+0.386	+3.008	.001	.016	3	1
LARGE_INTESTINE	Vinorelbine →	+0.725	+2.807	.021	.046	3	1
LARGE_INTESTINE	Brivanib →	+0.335	+2.874	.043	.021	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

Eg5_9814 by GFRA2 expression — LARGE_INTESTINE

Explore this box plot interactively →