GFPT2

Across TCGA pan-cancer cohorts, GFPT2 Mutation is linked to patient survival in 11 of 34 cancer types, making it a survival-associated GFPT2 data layer compared with 27 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher GFPT2 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated GFPT2 expression acts as an unfavorable survival marker, although some lineages such as UCEC and BLCA show a favorable association.

COAD, UCEC, and READ are the cancer types where GFPT2 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Median	III,IV	0.056	0.787	<.001	30	view →
UCEC	DFS	Median	All	0.973	0.619	.003	20	view →
READ	OS	Median	II,III,IV	0.527	0.933	<.001	9	view →
STAD	OS	Median	III,IV	0.169	0.641	.001	9	view →
KIRP	OS	Median	All	0.731	0.949	.003	8	view →
CESC	DFS	Median	III,IV	0.158	0.645	<.001	6	view →
PRAD	DFS	Median	All	0.065	0.774	<.001	6	view →
LUAD	OS	Median	All	0.235	0.697	.010	6	view →
LUSC	DFS	Median	II,III,IV	0.199	0.748	.006	6	view →
SKCM	DFS	Median	III,IV	0.188	0.652	.045	4	view →
BLCA	DFS	Median	All	1.000	0.609	.049	2	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

GFPT2–COAD (OS)

Open the COAD breakdown →