GFPT2

Across TCGA patient cohorts, GFPT2 mutation is significantly associated with the total protein of many other genes, with 53 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GFPT2-associated genes across cancer lineages are ATM, Caspase-7-cleavedD198, and eEF2. Each is linked with GFPT2 in more than 2 cancer types. Because this analysis shows association rather than direction, both GFPT2-to-partner and partner-to-GFPT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by GFPT2-low versus GFPT2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GFPT2→partner) and Y-score (partner→GFPT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.457	-1.986	<.001	.008	3	3
COAD	Caspase-7-cleavedD198 →	+1.132	+2.178	.002	.035	3	2
UCEC	eEF2 →	+0.273	+1.678	.011	.019	3	2
UCEC	INPP4B →	-0.224	-1.765	.022	.011	3	2
UCEC	PCNA →	+0.204	+1.530	.001	.004	3	2
UCEC	PDCD4 →	-0.357	-1.125	.012	.033	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 53 associations by consensus.

ATM by GFPT2 expression — UCEC

Explore this box plot interactively →