Across TCGA pan-cancer cohorts, GFPT1 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated GFPT1 data layer compared with 28 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher GFPT1 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated GFPT1 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UCEC, LGG, and LIHC are the cancer types where GFPT1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	II,III,IV	1.000	0.438	.014	26	view →
LGG	OS	Median	All	0.255	0.799	.001	12	view →
LIHC	OS	Median	All	0.015	0.784	<.001	12	view →
LUAD	DFS	Median	II,III,IV	0.098	0.682	<.001	10	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: GFPT1 tumor-vs-normal RNA expression · all GFPT1 data types