Across TCGA patient cohorts, GFPT1 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GFPT1-associated genes across cancer lineages are STAT5a, 14-3-3_beta, and Heregulin. Each is linked with GFPT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GFPT1-to-partner and partner-to-GFPT1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GFPT1→partner) and Y-score (partner→GFPT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT5a →	+0.468	+3.459	<.001	.005	3	2
UCEC	14-3-3_beta →	-0.107	-2.780	.002	.003	3	1
UCEC	Heregulin →	-0.102	-2.087	.017	.005	3	1
UCEC	JNK2 →	+0.152	+1.440	.027	.024	3	1
UCEC	MEK1 →	+0.263	+1.440	.038	.024	3	1
UCEC	Rab25 →	-0.272	-3.169	.017	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

Exploration

GFPT1 survival (RNA) · tumor vs normal (RNA) · all GFPT1 data types