GFOD1

Across TCGA pan-cancer cohorts, GFOD1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated GFOD1 data layer compared with 24 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher GFOD1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated GFOD1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and CCRCC show a favorable association.

HNSC, LUAD, and CCRCC are the cancer types where GFOD1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	III,IV	0.918	0.662	.009	24	view →
LUAD	DFS	Median	III,IV	0.239	0.732	.003	15	view →
CCRCC	DFS	Median	III,IV	0.787	0.229	.007	11	view →
PDAC	DFS	Tertile	III,IV	1.000	0.325	.024	9	view →
LSCC	OS	Tertile	All	0.970	0.788	.026	3	view →
GBM	DFS	Quartile	All	0.875	0.665	.042	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

GFOD1–HNSC (DFS)

Open the HNSC breakdown →