GFM2

Across TCGA patient cohorts, GFM2 mutation is significantly associated with the RNA expression of many other genes, with 2,714 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GFM2-associated genes across cancer lineages are RNU6-679P, TAPBPL, and GALNT6. Each is linked with GFM2 in more than 1 cancer types. Because this analysis shows association rather than direction, both GFM2-to-partner and partner-to-GFM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-679P grouped by GFM2-low versus GFM2-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GFM2→partner) and Y-score (partner→GFM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RNU6-679P →	+0.340	+5.763	<.001	.001	3	2
UCEC	TAPBPL →	-0.828	-2.313	<.001	.006	3	2
UCEC	GALNT6 →	-0.848	-2.289	<.001	.006	3	2
CESC	CLUHP5 →	+0.079	+5.812	<.001	.003	3	2
SKCM	RNU6-1287P →	+0.143	+4.186	<.001	.007	3	2
SKCM	RNU6-234P →	+0.263	+3.771	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,714 associations by consensus.

RNU6-679P by GFM2 expression — HNSC

Explore this box plot interactively →