GFM2

Across TCGA patient cohorts, GFM2 mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GFM2-associated genes across cancer lineages are Notch1, 14-3-3_beta, and eEF2. Each is linked with GFM2 in more than 1 cancer types. Because this analysis shows association rather than direction, both GFM2-to-partner and partner-to-GFM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by GFM2-low versus GFM2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GFM2→partner) and Y-score (partner→GFM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.121	+1.847	.019	.008	3	2
UCEC	14-3-3_beta →	-0.095	-2.432	.009	.018	3	1
UCEC	eEF2 →	+0.261	+2.321	.047	.033	3	1
UCEC	EGFR →	-0.156	-1.848	.008	.049	3	1
UCEC	A-Raf_pS299 →	-0.129	-2.000	.003	.030	3	1
UCEC	FASN →	+0.374	+1.847	.009	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

Notch1 by GFM2 expression — UCEC

Explore this box plot interactively →