GFM2

Across TCGA cell cohorts, GFM2 mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GFM2-associated genes across cancer lineages are TNP1, OR7A17, and HRG. Each is linked with GFM2 in more than 1 cancer types. Because this analysis shows association rather than direction, both GFM2-to-partner and partner-to-GFM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TNP1 grouped by GFM2-low versus GFM2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GFM2→partner) and Y-score (partner→GFM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TNP1 →	+0.172	+5.415	<.001	.004	3	1
LARGE_INTESTINE	OR7A17 →	+0.019	+5.415	<.001	.004	3	1
BLOOD_Leukemia	HRG →	+0.282	+3.177	<.001	.004	3	1
BLOOD_Leukemia	CPXCR1 →	+0.051	+4.234	.008	<.001	3	1
BLOOD_Leukemia	KSR2 →	+0.458	+4.061	<.001	.001	3	1
BLOOD_Leukemia	MAGEB6 →	+0.201	+3.300	.003	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

TNP1 by GFM2 expression — LARGE_INTESTINE

Explore this box plot interactively →