GFM1

Across TCGA patient cohorts, GFM1 mutation is significantly associated with the total protein of many other genes, with 52 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GFM1-associated genes across cancer lineages are C-Raf, FoxM1, and FOXO3a_pS318_S321. Each is linked with GFM1 in more than 2 cancer types. Because this analysis shows association rather than direction, both GFM1-to-partner and partner-to-GFM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf grouped by GFM1-low versus GFM1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GFM1→partner) and Y-score (partner→GFM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C-Raf →	+0.197	+2.115	<.001	.016	3	3
UCEC	FoxM1 →	+0.237	+2.137	.007	.001	3	2
UCEC	FOXO3a_pS318_S321 →	-0.103	-1.492	.015	.027	3	2
UCEC	PCNA →	+0.346	+2.662	<.001	<.001	3	2
UCEC	Src_pY527 →	-0.427	-2.405	.003	.003	3	2
UCEC	ASNS →	+0.428	+1.906	<.001	.015	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

C-Raf by GFM1 expression — UCEC

Explore this box plot interactively →