GFI1B

Across TCGA patient cohorts, GFI1B RNA expression is significantly associated with the go_rna of many other GO terms, with 7,000 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible GFI1B-associated GO terms across cancer lineages are Viral gene expression, Negative regulation of transferase activity, and Regulation of small GTPase mediated signal transduction. Each is linked with GFI1B in more than 17 cancer types. Because this analysis shows association rather than direction, both GFI1B-to-partner and partner-to-GFI1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Viral gene expression grouped by GFI1B-low versus GFI1B-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GFI1B→partner) and Y-score (partner→GFI1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Viral gene expression →	+0.084	+0.368	<.001	.004	3	18
ESCA	Negative regulation of transferase activity →	+0.069	+0.341	<.001	.002	3	17
STAD	Regulation of small GTPase mediated signal transduction →	+0.063	+0.356	<.001	.004	2	17
STAD	Alpha-beta T cell activation →	+0.063	+0.417	<.001	<.001	3	16
STAD	Antigen receptor-mediated signaling pathway →	+0.071	+0.461	<.001	<.001	2	16
ESCA	Negative regulation of protein serine/threonine kinase activity →	+0.058	+0.243	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,000 associations by consensus.

Viral gene expression by GFI1B expression — STAD

Explore this box plot interactively →