GFI1

Across TCGA patient cohorts, GFI1 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GFI1-associated genes across cancer lineages are MEK1, Notch1, and PDCD4. Each is linked with GFI1 in more than 2 cancer types. Because this analysis shows association rather than direction, both GFI1-to-partner and partner-to-GFI1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by GFI1-low versus GFI1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GFI1→partner) and Y-score (partner→GFI1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.363	+3.169	.048	.019	3	2
UCEC	Notch1 →	+0.240	+3.459	<.001	.005	3	2
UCEC	PDCD4 →	-0.869	-3.459	<.001	.005	3	2
UCEC	PDK1_pS241 →	+0.205	+3.321	.016	.010	3	2
UCEC	Bax →	+0.330	+2.321	.006	.035	3	2
UCEC	eIF4E →	+0.267	+3.013	.011	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

MEK1 by GFI1 expression — UCEC

Explore this box plot interactively →