GFI1

Across TCGA cell cohorts, GFI1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,079 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GFI1-associated GO terms across cancer lineages are Regulation of interleukin-6-mediated signaling pathway, Negative regulation of vitamin metabolic process, and Regulation of post-translational protein modification. Each is linked with GFI1 in more than 8 cancer types. Because this analysis shows association rather than direction, both GFI1-to-partner and partner-to-GFI1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of interleukin-6-mediated signaling pathway grouped by GFI1-low versus GFI1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GFI1→partner) and Y-score (partner→GFI1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulation of interleukin-6-mediated signaling pathway →	-0.292	-0.821	<.001	<.001	2	9
LARGE_INTESTINE	Negative regulation of vitamin metabolic process →	-0.129	-0.772	<.001	<.001	3	8
OESOPHAGUS	Regulation of post-translational protein modification →	+0.083	+1.228	<.001	<.001	3	7
OESOPHAGUS	Negative regulation of mRNA metabolic process →	+0.096	+1.225	<.001	<.001	3	7
OESOPHAGUS	Regulation of protein modification by small protein conjugation or removal →	+0.058	+1.009	.003	.001	3	7
OESOPHAGUS	Negative regulation of syncytium formation by plasma membrane fusion →	+0.145	+1.185	.002	.002	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,079 associations by consensus.

Regulation of interleukin-6-mediated signaling pathway by GFI1 expression — BONE

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