GFI1

Across TCGA cell cohorts, GFI1 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GFI1-associated genes across cancer lineages are FSHB, OR13C4, and NXF5. Each is linked with GFI1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GFI1-to-partner and partner-to-GFI1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FSHB grouped by GFI1-low versus GFI1-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GFI1→partner) and Y-score (partner→GFI1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	FSHB →	+0.012	+5.029	<.001	.006	3	1
LUNG_SCLC	OR13C4 →	+0.165	+5.029	<.001	.006	3	1
LARGE_INTESTINE	NXF5 →	+0.040	+4.467	<.001	.004	3	1
LARGE_INTESTINE	ELOA3DP →	+0.031	+4.273	<.001	.006	3	1
LARGE_INTESTINE	NUPR2 →	+0.376	+4.273	<.001	.006	3	1
LARGE_INTESTINE	KRTAP10-1 →	+0.009	+4.415	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

FSHB by GFI1 expression — LUNG_SCLC

Explore this box plot interactively →