GFAP

Across TCGA patient cohorts, GFAP mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GFAP-associated genes across cancer lineages are eEF2, FoxM1, and ATM. Each is linked with GFAP in more than 2 cancer types. Because this analysis shows association rather than direction, both GFAP-to-partner and partner-to-GFAP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by GFAP-low versus GFAP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GFAP→partner) and Y-score (partner→GFAP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.321	+3.169	.029	.018	3	3
UCEC	FoxM1 →	+0.224	+1.807	.036	.027	3	2
UCEC	ATM →	-0.705	-2.321	<.001	.006	3	2
UCEC	EGFR_pY1068 →	-0.207	-1.807	.045	.027	3	1
UCEC	eIF4E →	+0.176	+1.807	.043	.027	3	1
UCEC	INPP4B →	-0.325	-3.321	.014	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

eEF2 by GFAP expression — UCEC

Explore this box plot interactively →