GFAP

Across TCGA cell cohorts, GFAP mutation is significantly associated with the RNA expression of many other genes, with 17 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GFAP-associated genes across cancer lineages are TAAR8, SPATA31D1, and OPN4. Each is linked with GFAP in more than 1 cancer types. Because this analysis shows association rather than direction, both GFAP-to-partner and partner-to-GFAP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TAAR8 grouped by GFAP-low versus GFAP-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GFAP→partner) and Y-score (partner→GFAP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	TAAR8 →	+0.022	+5.662	<.001	.002	3	1
LUNG_NSCLC_LUAD	SPATA31D1 →	+0.006	+5.228	<.001	.005	3	1
LARGE_INTESTINE	OPN4 →	+0.013	+4.930	.007	.001	3	1
LARGE_INTESTINE	MSGN1 →	+0.089	+4.930	<.001	.001	3	1
LARGE_INTESTINE	TAFA1 →	+0.418	+4.273	<.001	.006	3	1
LARGE_INTESTINE	MINAR2 →	+0.053	+4.467	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

TAAR8 by GFAP expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →