GET4

Across TCGA cell cohorts, GET4 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,435 significant associations in total. BONE shows the largest number of these associations.

The most reproducible GET4-associated GO terms across cancer lineages are Maintenance of unfolded protein, Negative regulation of autophagy, and Post-translational protein targeting to endoplasmic reticulum membrane. Each is linked with GET4 in more than 18 cancer types. Because this analysis shows association rather than direction, both GET4-to-partner and partner-to-GET4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Maintenance of unfolded protein grouped by GET4-low versus GET4-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GET4→partner) and Y-score (partner→GET4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Maintenance of unfolded protein →	+0.159	+0.890	<.001	<.001	3	19
BREAST	Negative regulation of autophagy →	+0.066	+0.904	<.001	<.001	3	15
BONE	Post-translational protein targeting to endoplasmic reticulum membrane →	+0.145	+1.134	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	Meiotic telomere tethering at nuclear periphery →	+0.171	+1.348	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	Meiotic telomere clustering →	+0.171	+1.348	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	Meiotic attachment of telomere to nuclear envelope →	+0.171	+1.348	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,435 associations by consensus.

Maintenance of unfolded protein by GET4 expression — OESOPHAGUS

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