GET4

Across TCGA cell cohorts, GET4 mutation is significantly associated with the mutation status of many other genes, with 1,500 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GET4-associated genes across cancer lineages are LIG3, SMARCA4, and CACNA1C. Each is linked with GET4 in more than 2 cancer types. Because this analysis shows association rather than direction, both GET4-to-partner and partner-to-GET4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LIG3 grouped by GET4-low versus GET4-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GET4→partner) and Y-score (partner→GET4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	LIG3 →	+4.870	+4.560	<.001	<.001	1	3
BREAST	SMARCA4 →	+3.222	+3.754	.001	.001	1	3
BREAST	CACNA1C →	+2.900	+3.557	.002	.002	1	3
BLOOD_Leukemia	BCL11B →	+2.197	+3.280	.007	.007	1	3
BLOOD_Lymphoma	LEPR →	+4.429	+5.247	.005	.005	1	3
LARGE_INTESTINE	SBF1 →	+1.807	+3.898	.001	.001	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,500 associations by consensus.

LIG3 by GET4 expression — BLOOD_Leukemia

Explore this box plot interactively →