GET4

Across TCGA cell cohorts, GET4 mutation is significantly associated with the drug of many other genes, with 32 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GET4-associated genes across cancer lineages are Lenalidomide, Wnt-C59, and IRAK4_4710. Each is linked with GET4 in more than 1 cancer types. Because this analysis shows association rather than direction, both GET4-to-partner and partner-to-GET4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Lenalidomide grouped by GET4-low versus GET4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GET4→partner) and Y-score (partner→GET4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Lenalidomide →	+0.291	+2.684	.045	.035	3	1
LARGE_INTESTINE	Wnt-C59 →	+0.386	+2.678	.027	.037	3	1
LARGE_INTESTINE	IRAK4_4710 →	+0.488	+2.649	.006	.046	3	1
LARGE_INTESTINE	GSK3337463A →	+0.423	+2.649	.012	.046	3	1
LARGE_INTESTINE	Sinularin →	+0.368	+2.777	.018	.038	3	1
LARGE_INTESTINE	Zibotentan →	+0.257	+2.710	.010	.027	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

Lenalidomide by GET4 expression — LARGE_INTESTINE

Explore this box plot interactively →