GET1

Across TCGA patient cohorts, GET1 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GET1-associated genes across cancer lineages are p70-S6K, FoxM1, and p27_pT198. Each is linked with GET1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GET1-to-partner and partner-to-GET1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p70-S6K grouped by GET1-low versus GET1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GET1→partner) and Y-score (partner→GET1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p70-S6K →	+0.248	+3.026	.025	.019	3	1
UCEC	FoxM1 →	+0.397	+3.000	.007	.037	1	1
UCEC	p27_pT198 →	+0.170	+3.000	.005	.037	1	1
UCEC	PCNA →	+0.365	+3.000	.003	.037	1	1
UCEC	STAT5a →	+0.461	+3.000	.046	.037	1	1
UCEC	Claudin-7 →	-0.682	-3.000	.019	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

p70-S6K by GET1 expression — UCEC

Explore this box plot interactively →