GEN1

Across TCGA patient cohorts, GEN1 RNA expression is significantly associated with the RNA expression of many other genes, with 20,195 significant associations in total. UVM shows the largest number of these associations.

The most reproducible GEN1-associated genes across cancer lineages are ZNF107, PIKFYVE, and BIRC6. Each is linked with GEN1 in more than 33 cancer types. Because this analysis shows association rather than direction, both GEN1-to-partner and partner-to-GEN1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GEN1 versus ZNF107 in DLBC, with a Pearson correlation of 0.58.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GEN1→partner) and Y-score (partner→GEN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
DLBC	ZNF107 →	+1.835	+1.615	<.001	<.001	3	34
UVM	PIKFYVE →	+1.555	+1.431	<.001	<.001	3	34
UVM	BIRC6 →	+1.402	+1.421	<.001	<.001	3	34
UVM	TIA1 →	+2.200	+1.408	<.001	<.001	3	34
UVM	ATAD2B →	+1.089	+1.426	<.001	<.001	3	34
UVM	RCBTB1 →	+1.706	+1.343	<.001	<.001	3	34

Each partner links to its Q-omics profile. Showing the 6 strongest of 20,195 associations by consensus.

GEN1 vs ZNF107 — DLBC

Explore this scatter interactively →