GEN1

Across TCGA patient cohorts, GEN1 mutation is significantly associated with the RNA expression of many other genes, with 1,613 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GEN1-associated genes across cancer lineages are HPGDS, FAM110B, and LINC02209. Each is linked with GEN1 in more than 2 cancer types. Because this analysis shows association rather than direction, both GEN1-to-partner and partner-to-GEN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HPGDS grouped by GEN1-low versus GEN1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GEN1→partner) and Y-score (partner→GEN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HPGDS →	-0.416	-1.882	<.001	<.001	3	3
UCEC	FAM110B →	-0.892	-1.882	<.001	<.001	3	3
CESC	LINC02209 →	+0.017	+3.653	<.001	.009	3	2
UCEC	SAR1B →	+0.414	+1.893	<.001	<.001	3	2
UCEC	CD8A →	+0.830	+3.087	<.001	<.001	3	2
UCEC	GFI1 →	+0.389	+1.914	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,613 associations by consensus.

HPGDS by GEN1 expression — UCEC

Explore this box plot interactively →