GEN1

Across TCGA patient cohorts, GEN1 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GEN1-associated genes across cancer lineages are TIGAR, Caspase-7-cleavedD198, and ERK2. Each is linked with GEN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GEN1-to-partner and partner-to-GEN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TIGAR grouped by GEN1-low versus GEN1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GEN1→partner) and Y-score (partner→GEN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TIGAR →	+0.120	+1.486	.014	.007	3	2
UCEC	Caspase-7-cleavedD198 →	+0.595	+1.697	.001	.012	3	2
UCEC	ERK2 →	+0.126	+2.000	.044	.029	3	1
UCEC	JNK2 →	+0.195	+1.459	.002	.012	3	1
UCEC	MEK1 →	+0.264	+1.502	.026	.027	3	1
UCEC	PCNA →	+0.151	+1.222	.031	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

TIGAR by GEN1 expression — UCEC

Explore this box plot interactively →