GEN1

Across TCGA cell cohorts, GEN1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,689 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible GEN1-associated GO terms across cancer lineages are Regulation of centrosome duplication, Negative regulation of G2/M transition of mitotic cell cycle, and Regulation of metaphase/anaphase transition of cell cycle. Each is linked with GEN1 in more than 19 cancer types. Because this analysis shows association rather than direction, both GEN1-to-partner and partner-to-GEN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of centrosome duplication grouped by GEN1-low versus GEN1-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GEN1→partner) and Y-score (partner→GEN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Regulation of centrosome duplication →	+0.110	+1.226	.001	.001	3	20
OVARY	Negative regulation of G2/M transition of mitotic cell cycle →	+0.092	+1.115	<.001	<.001	3	20
OESOPHAGUS	Regulation of metaphase/anaphase transition of cell cycle →	+0.140	+1.080	<.001	<.001	3	20
OESOPHAGUS	Regulation of cell cycle G2/M phase transition →	+0.095	+1.296	<.001	<.001	3	20
OVARY	Negative regulation of cell cycle G2/M phase transition →	+0.091	+1.113	<.001	<.001	3	20
OESOPHAGUS	Regulation of mitotic metaphase/anaphase transition →	+0.145	+1.080	<.001	<.001	3	20

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,689 associations by consensus.

Regulation of centrosome duplication by GEN1 expression — OESOPHAGUS

Explore this box plot interactively →