GEN1

Across TCGA cell cohorts, GEN1 mutation is significantly associated with the RNA expression of many other genes, with 17 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GEN1-associated genes across cancer lineages are NPHS2, NXF5, and LRFN5. Each is linked with GEN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GEN1-to-partner and partner-to-GEN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NPHS2 grouped by GEN1-low versus GEN1-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GEN1→partner) and Y-score (partner→GEN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	NPHS2 →	+0.150	+4.044	.001	.001	3	1
URINARY_TRACT	NXF5 →	+0.045	+4.321	<.001	.001	3	1
URINARY_TRACT	LRFN5 →	+1.242	+3.584	<.001	.009	3	1
URINARY_TRACT	PRR23A →	+0.022	+3.584	<.001	.005	3	1
BLOOD_Leukemia	LRRTM1 →	+0.609	+4.321	<.001	.002	3	1
BLOOD_Leukemia	SLC38A11 →	+0.122	+3.852	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

NPHS2 by GEN1 expression — URINARY_TRACT

Explore this box plot interactively →