GEMIN8

Across TCGA pan-cancer cohorts, GEMIN8 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated GEMIN8 data layer compared with 22 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher GEMIN8 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated GEMIN8 expression acts as an unfavorable survival marker, although some lineages such as COAD and LUAD show a favorable association.

CCRCC, COAD, and HNSC are the cancer types where GEMIN8 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Tertile	All	0.573	1.000	.009	21	view →
COAD	DFS	Median	IV	1.000	0.605	.043	6	view →
HNSC	DFS	Tertile	III,IV	0.714	0.905	.029	6	view →
LSCC	OS	Quartile	III,IV	0.610	0.912	.026	4	view →
PDAC	DFS	Median	III,IV	0.366	0.727	.014	3	view →
LUAD	DFS	Median	III,IV	0.972	0.508	.049	1	view →
GBM	DFS	Quartile	All	0.652	0.848	.044	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

GEMIN8–CCRCC (OS)

Open the CCRCC breakdown →