GEMIN8

Across TCGA patient cohorts, GEMIN8 protein abundance is significantly associated with the RNA expression of many other genes, with 6,576 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible GEMIN8-associated genes across cancer lineages are SMN1, NUP155, and CENPK. Each is linked with GEMIN8 in more than 5 cancer types. Because this analysis shows association rather than direction, both GEMIN8-to-partner and partner-to-GEMIN8 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GEMIN8 versus SMN1 in HNSC, with a Pearson correlation of 0.33.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GEMIN8→partner) and Y-score (partner→GEMIN8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SMN1 →	+0.481	+0.272	.003	<.001	3	6
LSCC	NUP155 →	+0.494	+0.266	.001	<.001	3	4
LSCC	CENPK →	+0.569	+0.216	.002	<.001	3	4
HNSC	CDC25C →	+0.925	+0.341	<.001	<.001	3	4
HNSC	CDKN2AIPNL →	+0.711	+0.232	.001	<.001	3	4
LSCC	SMN2 →	+0.732	+0.286	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,576 associations by consensus.

GEMIN8 vs SMN1 — HNSC

Explore this scatter interactively →