GEMIN8

Across TCGA patient cohorts, GEMIN8 mutation is significantly associated with the RNA expression of many other genes, with 1,684 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GEMIN8-associated genes across cancer lineages are RNU6-252P, OR8B6P, and LCEP4. Each is linked with GEMIN8 in more than 2 cancer types. Because this analysis shows association rather than direction, both GEMIN8-to-partner and partner-to-GEMIN8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-252P grouped by GEMIN8-low versus GEMIN8-high in GBM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GEMIN8→partner) and Y-score (partner→GEMIN8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RNU6-252P →	+0.877	+5.584	<.001	.003	3	3
GBM	OR8B6P →	+0.088	+6.614	<.001	<.001	3	2
SKCM	LCEP4 →	+0.334	+3.018	<.001	.009	3	2
COAD	LINC01335 →	+0.387	+5.080	<.001	.008	3	2
SKCM	LINC02707 →	+0.089	+3.622	.003	.005	3	2
SKCM	MIR3689F →	+0.257	+4.147	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,684 associations by consensus.

RNU6-252P by GEMIN8 expression — GBM

Explore this box plot interactively →