GEMIN6

Across TCGA pan-cancer cohorts, GEMIN6 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated GEMIN6 data layer compared with 25 for mass-spec protein.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher GEMIN6 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated GEMIN6 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LSCC show a favorable association.

CCRCC, UCEC, and LUAD are the cancer types where GEMIN6 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	All	0.709	1.000	.010	23	view →
UCEC	DFS	Quartile	III,IV	1.000	0.270	.013	12	view →
LUAD	DFS	Median	III,IV	0.409	0.941	.010	11	view →
HNSC	DFS	Median	All	0.331	0.871	.018	8	view →
LSCC	DFS	Quartile	II,III,IV	1.000	0.844	.048	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

GEMIN6–CCRCC (DFS)

Open the CCRCC breakdown →