GEMIN6

Across TCGA patient cohorts, GEMIN6 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GEMIN6-associated genes across cancer lineages are EGFR_pY1068, ERK2, and Ku80. Each is linked with GEMIN6 in more than 1 cancer types. Because this analysis shows association rather than direction, both GEMIN6-to-partner and partner-to-GEMIN6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by GEMIN6-low versus GEMIN6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GEMIN6→partner) and Y-score (partner→GEMIN6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.360	-3.000	.013	.037	3	1
UCEC	ERK2 →	+0.290	+3.000	.009	.037	3	1
UCEC	Ku80 →	+0.273	+3.013	.045	.019	3	1
UCEC	Tuberin_pT1462 →	+0.343	+3.000	.010	.037	3	1
UCEC	Tuberin →	+0.537	+3.009	<.001	.019	3	1
UCEC	Caspase-8 →	-0.299	-3.000	.039	.036	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

EGFR_pY1068 by GEMIN6 expression — UCEC

Explore this box plot interactively →