GEMIN5

Across TCGA pan-cancer cohorts, GEMIN5 Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated GEMIN5 data layer compared with 23 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher GEMIN5 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated GEMIN5 expression acts as an unfavorable survival marker, although some lineages such as SKCM and UCEC show a favorable association.

HNSC, BLCA, and SKCM are the cancer types where GEMIN5 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	IV	0.002	0.734	<.001	12	view →
BLCA	OS	Median	III,IV	0.193	0.585	.001	9	view →
SKCM	DFS	Median	II,III,IV	0.884	0.533	.007	9	view →
LIHC	OS	Median	All	0.008	0.775	<.001	6	view →
UCEC	DFS	Median	All	0.913	0.617	.017	4	view →
LUSC	DFS	Median	II,III,IV	0.199	0.748	.006	3	view →
COAD	OS	Median	II,III,IV	0.581	0.856	.036	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

GEMIN5–HNSC (OS)

Open the HNSC breakdown →