GEMIN5

Across TCGA patient cohorts, GEMIN5 mutation is significantly associated with the total protein of many other genes, with 55 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GEMIN5-associated genes across cancer lineages are PRDX1, 4E-BP1, and eIF4E. Each is linked with GEMIN5 in more than 2 cancer types. Because this analysis shows association rather than direction, both GEMIN5-to-partner and partner-to-GEMIN5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRDX1 grouped by GEMIN5-low versus GEMIN5-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GEMIN5→partner) and Y-score (partner→GEMIN5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PRDX1 →	+0.145	+1.900	.022	.030	3	3
COAD	4E-BP1 →	+0.215	+1.882	.019	.031	3	3
UCEC	eIF4E →	+0.159	+2.392	.010	<.001	3	3
UCEC	mTOR_pS2448 →	-0.101	-1.794	.021	.024	3	3
UCEC	PCNA →	+0.127	+1.058	.046	.037	3	3
UCEC	TFRC →	+0.419	+1.502	.007	.027	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 55 associations by consensus.

PRDX1 by GEMIN5 expression — COAD

Explore this box plot interactively →