GEMIN4

Across TCGA pan-cancer cohorts, GEMIN4 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated GEMIN4 data layer compared with 24 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher GEMIN4 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated GEMIN4 expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

CCRCC, LUAD, and PDAC are the cancer types where GEMIN4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	All	0.605	1.000	.001	17	view →
LUAD	DFS	Median	III,IV	0.409	0.941	.010	8	view →
PDAC	OS	Median	II,III,IV	0.448	0.597	.023	5	view →
HNSC	DFS	Quartile	II,III,IV	0.772	0.512	.027	2	view →
UCEC	DFS	Tertile	All	0.754	0.919	.049	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

GEMIN4–CCRCC (OS)

Open the CCRCC breakdown →