GEMIN4

Across TCGA patient cohorts, GEMIN4 mutation is significantly associated with the RNA expression of many other genes, with 2,394 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GEMIN4-associated genes across cancer lineages are ATP6V1B2, PBK, and RN7SL352P. Each is linked with GEMIN4 in more than 2 cancer types. Because this analysis shows association rather than direction, both GEMIN4-to-partner and partner-to-GEMIN4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATP6V1B2 grouped by GEMIN4-low versus GEMIN4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GEMIN4→partner) and Y-score (partner→GEMIN4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATP6V1B2 →	+0.387	+3.807	.002	<.001	3	3
UCEC	PBK →	+0.826	+2.443	<.001	<.001	3	3
SKCM	RN7SL352P →	+0.089	+4.469	<.001	<.001	3	2
HNSC	OR5AN1 →	+0.048	+6.468	<.001	.001	3	2
UCEC	CCL5 →	+0.843	+2.186	.003	.001	3	2
UCEC	UHRF1 →	+0.780	+2.126	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,394 associations by consensus.

ATP6V1B2 by GEMIN4 expression — UCEC

Explore this box plot interactively →