GEMIN4

Across TCGA patient cohorts, GEMIN4 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GEMIN4-associated genes across cancer lineages are p53, PKC-a_pS657, and Rictor. Each is linked with GEMIN4 in more than 1 cancer types. Because this analysis shows association rather than direction, both GEMIN4-to-partner and partner-to-GEMIN4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p53 grouped by GEMIN4-low versus GEMIN4-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GEMIN4→partner) and Y-score (partner→GEMIN4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	p53 →	-0.341	-2.991	.042	.036	3	2
COAD	PKC-a_pS657 →	-0.371	-2.991	.020	.036	3	1
COAD	Rictor →	-1.054	-2.991	.042	.036	3	1
COAD	TSC1 →	-0.464	-3.000	.001	.034	3	1
COAD	Bad_pS112 →	-0.205	-2.991	.044	.036	3	1
UCEC	EGFR_pY1068 →	-0.176	-1.362	.047	.037	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

p53 by GEMIN4 expression — COAD

Explore this box plot interactively →