GEMIN4

Across TCGA cell cohorts, GEMIN4 mutation is significantly associated with the RNA expression of many other genes, with 32 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible GEMIN4-associated genes across cancer lineages are CLRN2, CRISP1, and SMCP. Each is linked with GEMIN4 in more than 1 cancer types. Because this analysis shows association rather than direction, both GEMIN4-to-partner and partner-to-GEMIN4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CLRN2 grouped by GEMIN4-low versus GEMIN4-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GEMIN4→partner) and Y-score (partner→GEMIN4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	CLRN2 →	+0.036	+4.523	<.001	.004	3	2
CNS	CRISP1 →	+0.006	+5.321	.004	.005	3	1
CNS	SMCP →	+0.183	+5.321	<.001	.005	3	1
CNS	LCE3E →	+0.401	+5.754	<.001	.002	3	1
SKIN	TPPP2 →	+0.054	+5.217	<.001	<.001	3	1
SKIN	BHLHA9 →	+0.034	+4.273	.003	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

CLRN2 by GEMIN4 expression — BLOOD_Lymphoma

Explore this box plot interactively →