GEM

Across TCGA pan-cancer cohorts, GEM mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated GEM data layer compared with 21 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher GEM mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated GEM expression acts as an unfavorable survival marker, although some lineages such as PDAC and CCRCC show a favorable association.

PDAC, CCRCC, and LUAD are the cancer types where GEM mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Median	III,IV	0.558	0.255	.001	52	view →
CCRCC	DFS	Median	III,IV	0.904	0.105	.008	35	view →
LUAD	DFS	Quartile	II,III,IV	0.724	1.000	.017	5	view →
LSCC	OS	Quartile	II,III,IV	0.752	1.000	.022	4	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

GEM–PDAC (OS)

Open the PDAC breakdown →