GEM

Across TCGA patient cohorts, GEM RNA expression is significantly associated with the protein abundance of many other proteins, with 19,959 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible GEM-associated proteins across cancer lineages are MYLK, MYO1C, and VCL_S346. Each is linked with GEM in more than 8 cancer types. Because this analysis shows association rather than direction, both GEM-to-partner and partner-to-GEM results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GEM versus MYLK in UCEC, with a Pearson correlation of 0.55.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (GEM→partner) and Y-score (partner→GEM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MYLK →	+0.753	+0.983	<.001	<.001	3	9
OV	MYO1C →	+0.572	+1.404	.001	<.001	3	9
BRCA	VCL_S346 →	+0.594	+1.052	.002	<.001	3	9
UCEC	ILK →	+0.546	+1.142	<.001	<.001	3	9
UCEC	KANK2 →	+0.645	+1.046	<.001	<.001	3	9
CCRCC	LMCD1 →	+0.713	+0.938	<.001	.002	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,959 associations by consensus.

GEM vs MYLK — UCEC

Explore this scatter interactively →