GEM

Across TCGA patient cohorts, GEM protein abundance is significantly associated with the RNA expression of many other genes, with 8,351 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible GEM-associated genes across cancer lineages are MGP, RASL12, and CPED1. Each is linked with GEM in more than 6 cancer types. Because this analysis shows association rather than direction, both GEM-to-partner and partner-to-GEM results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GEM versus MGP in HNSC, with a Pearson correlation of 0.70.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GEM→partner) and Y-score (partner→GEM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	MGP →	+2.369	+0.847	<.001	.001	3	7
UCEC	RASL12 →	+0.891	+0.592	<.001	.001	3	6
UCEC	CPED1 →	+0.928	+0.555	<.001	.001	3	6
UCEC	PLSCR4 →	+0.951	+0.653	<.001	<.001	3	6
CCRCC	PLCL1 →	+0.774	+0.557	.002	<.001	3	6
BRCA	AOC3 →	+1.244	+0.757	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,351 associations by consensus.

GEM vs MGP — HNSC

Explore this scatter interactively →