GEM

Across TCGA patient cohorts, GEM mutation is significantly associated with the RNA expression of many other genes, with 829 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GEM-associated genes across cancer lineages are CHAF1A, ZNF843, and NCAPH2. Each is linked with GEM in more than 1 cancer types. Because this analysis shows association rather than direction, both GEM-to-partner and partner-to-GEM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CHAF1A grouped by GEM-low versus GEM-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GEM→partner) and Y-score (partner→GEM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CHAF1A →	+0.581	+2.343	.003	.003	3	2
UCEC	ZNF843 →	-0.338	-2.279	.008	.006	3	2
UCEC	NCAPH2 →	+0.606	+3.000	<.001	.001	3	2
UCEC	WDR62 →	+0.634	+3.010	.001	<.001	3	2
UCEC	POLR2E →	+0.441	+3.000	.005	.001	3	2
LUAD	OR3B1P →	+0.044	+4.303	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 829 associations by consensus.

CHAF1A by GEM expression — UCEC

Explore this box plot interactively →