GEM

Across TCGA cell cohorts, GEM RNA expression is significantly associated with the go_rna of many other GO terms, with 4,558 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible GEM-associated GO terms across cancer lineages are Neuropilin signaling pathway, Serotonin transport, and Actin filament fragmentation. Each is linked with GEM in more than 11 cancer types. Because this analysis shows association rather than direction, both GEM-to-partner and partner-to-GEM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Neuropilin signaling pathway grouped by GEM-low versus GEM-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GEM→partner) and Y-score (partner→GEM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Neuropilin signaling pathway →	+0.212	+1.553	.002	.002	3	12
URINARY_TRACT	Serotonin transport →	-1.394	-2.320	<.001	<.001	3	11
BONE	Actin filament fragmentation →	+0.119	+1.863	<.001	.009	3	11
LIVER	Negative regulation of peptidase activity →	+0.330	+2.201	<.001	<.001	3	10
BREAST	Positive regulation of focal adhesion assembly →	+0.179	+2.107	<.001	.002	3	10
BLOOD_Lymphoma	Negative regulation of metallopeptidase activity →	+1.165	+1.844	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,558 associations by consensus.

Neuropilin signaling pathway by GEM expression — BONE

Explore this box plot interactively →