GEM

Across TCGA cell cohorts, GEM mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GEM-associated genes across cancer lineages are RFPL3, KRTAP10-1, and OR5V1. Each is linked with GEM in more than 1 cancer types. Because this analysis shows association rather than direction, both GEM-to-partner and partner-to-GEM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RFPL3 grouped by GEM-low versus GEM-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GEM→partner) and Y-score (partner→GEM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	RFPL3 →	+0.058	+4.095	<.001	.009	3	1
LARGE_INTESTINE	KRTAP10-1 →	+0.009	+4.415	<.001	.007	3	1
LARGE_INTESTINE	OR5V1 →	+0.010	+5.022	<.001	.002	3	1
BLOOD_Leukemia	CCDC172 →	+0.125	+5.201	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

RFPL3 by GEM expression — LARGE_INTESTINE

Explore this box plot interactively →