GDPD5

Across TCGA cell cohorts, GDPD5 mutation is significantly associated with the drug of many other genes, with 15 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GDPD5-associated genes across cancer lineages are Pevonedistat, KRAS (G12C) Inhibitor-12, and N25720-51-A1. Each is linked with GDPD5 in more than 1 cancer types. Because this analysis shows association rather than direction, both GDPD5-to-partner and partner-to-GDPD5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Pevonedistat grouped by GDPD5-low versus GDPD5-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GDPD5→partner) and Y-score (partner→GDPD5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Pevonedistat →	+0.723	+2.649	.036	.046	3	1
LARGE_INTESTINE	KRAS (G12C) Inhibitor-12 →	+0.493	+2.868	.037	.022	3	1
LARGE_INTESTINE	N25720-51-A1 →	+0.470	+2.655	.018	.044	3	1
LARGE_INTESTINE	Ispinesib Mesylate →	+0.664	+2.874	.032	.021	3	1
LARGE_INTESTINE	Cytarabine →	+0.884	+2.655	.022	.044	2	1
LARGE_INTESTINE	IWP-2 →	+0.282	+3.115	.025	.015	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

Pevonedistat by GDPD5 expression — LARGE_INTESTINE

Explore this box plot interactively →