GDPD4

Across TCGA pan-cancer cohorts, GDPD4 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of GDPD4’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where GDPD4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types GDPD4 is over-expressed in tumor, although a few such as BRCA and KIRP show the opposite, repressed pattern.

HNSC, KIRC, and BRCA are the cancer types where GDPD4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GDPD4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.103	<.001	11	view →
KIRC	All	All	+0.153	<.001	8	view →
BRCA	All	III,IV	−0.104	<.001	6	view →
LUAD	All	All	+0.179	<.001	4	view →
KIRP	All	II,III,IV	−0.112	.024	4	view →
STAD	All	All	+0.056	.030	4	view →
ESCA	All	II,III,IV	+0.140	.019	2	view →
THCA	All	All	−0.072	.020	2	view →
PRAD	All	All	−0.055	.019	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

GDPD4–HNSC

Open the HNSC breakdown →