GDPD1

Across TCGA patient cohorts, GDPD1 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GDPD1-associated genes across cancer lineages are p21, VEGFR2, and EGFR_pY1068. Each is linked with GDPD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GDPD1-to-partner and partner-to-GDPD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p21 grouped by GDPD1-low versus GDPD1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GDPD1→partner) and Y-score (partner→GDPD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p21 →	+0.181	+2.000	.037	.032	3	2
UCEC	VEGFR2 →	+0.364	+2.013	.006	.018	3	2
UCEC	EGFR_pY1068 →	-0.306	-3.321	.006	.009	3	1
UCEC	A-Raf_pS299 →	-0.121	-2.999	.024	.035	3	1
UCEC	GAPDH →	+0.553	+2.999	.022	.035	3	1
UCEC	IGFBP2 →	-0.688	-2.000	.018	.032	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

p21 by GDPD1 expression — UCEC

Explore this box plot interactively →