GDNF

Across TCGA pan-cancer cohorts, GDNF Mutation is linked to patient survival in 8 of 34 cancer types, making it a survival-associated GDNF data layer compared with 17 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher GDNF Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated GDNF expression acts as an unfavorable survival marker.

BLCA, LUAD, and COAD are the cancer types where GDNF Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	DFS	Median	All	0.167	0.618	<.001	45	view →
LUAD	DFS	Median	All	0.193	0.773	<.001	32	view →
COAD	OS	Median	II,III,IV	0.624	0.856	.004	9	view →
PRAD	DFS	Median	All	0.085	0.774	.001	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
LUSC	DFS	Median	II,III,IV	0.139	0.663	.027	4	view →
SKCM	DFS	Median	All	0.366	0.623	.015	4	view →
READ	OS	Median	All	0.281	0.830	.006	3	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

GDNF–BLCA (DFS)

Open the BLCA breakdown →