GDNF

Across TCGA patient cohorts, GDNF mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GDNF-associated genes across cancer lineages are FOXO3a_pS318_S321, MEK1, and PCNA. Each is linked with GDNF in more than 1 cancer types. Because this analysis shows association rather than direction, both GDNF-to-partner and partner-to-GDNF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a_pS318_S321 grouped by GDNF-low versus GDNF-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GDNF→partner) and Y-score (partner→GDNF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3a_pS318_S321 →	-0.133	-1.990	.010	.030	3	2
UCEC	MEK1 →	+0.518	+3.000	<.001	.001	3	2
UCEC	PCNA →	+0.260	+2.999	.003	.035	3	2
UCEC	PKC-b-II_pS660 →	-0.230	-1.807	.044	.027	3	2
UCEC	Annexin_VII →	-0.114	-2.312	.046	.034	3	2
UCEC	Di-Ras3 →	-0.182	-4.087	.002	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

FOXO3a_pS318_S321 by GDNF expression — UCEC

Explore this box plot interactively →