GDNF

Across TCGA cell cohorts, GDNF RNA expression is significantly associated with the go_rna of many other GO terms, with 2,323 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible GDNF-associated GO terms across cancer lineages are Regulation of semaphorin-plexin signaling pathway, Peristalsis, and Regulation of calcineurin-mediated signaling. Each is linked with GDNF in more than 9 cancer types. Because this analysis shows association rather than direction, both GDNF-to-partner and partner-to-GDNF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of semaphorin-plexin signaling pathway grouped by GDNF-low versus GDNF-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GDNF→partner) and Y-score (partner→GDNF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Regulation of semaphorin-plexin signaling pathway →	+1.029	+2.873	<.001	<.001	3	10
SKIN	Peristalsis →	+1.935	+3.810	<.001	<.001	3	10
KIDNEY	Regulation of calcineurin-mediated signaling →	+0.116	+1.034	<.001	.006	3	7
BLOOD_Myeloma	Mesonephric tubule formation →	+1.567	+2.815	<.001	<.001	3	7
KIDNEY	Regulation of calcineurin-NFAT signaling cascade →	+0.116	+1.034	<.001	.006	3	7
SOFT_TISSUE	Regulation of protein maturation →	+0.146	+1.513	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,323 associations by consensus.

Regulation of semaphorin-plexin signaling pathway by GDNF expression — SKIN

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